Tilman M. Hackeng

Position: Professor and Chair Biochemistry; director CARIM

Bio: My choice for biochemical research of blood clotting proteins was made in the late eighties during a lab rotation when I studied biochemistry at the University of Utrecht. I obtained my Ph.D. with Prof. Bouma at the same University in 1993 on protein C/protein S anticoagulant mechanisms.  Shortly after, I left for The Scripps Research Institute, La Jolla, CA, USA, were I worked in the laboratories of Profs. Griffin and Kent. In 1998 I returned to the Netherlands as a Research Fellow of the Royal Netherlands Academy of Arts and Sciences (KNAW) in the group of Prof. Rosing at the Department of Biochemistry of the University Maastricht. My group studies the anticoagulant protein C/protein S/TFPI pathways in a biochemical and curiosity-driven way and applies total chemical protein synthesis to structure-function analysis of coagulation proteins in general. As part of the Maastricht Imaging Valley initiative, we design and synthesize peptide/protein-based contrast agents for targeted molecular imaging of cardiovascular disease. I am past president of the Netherlands Society on Thrombosis and Hemostasis (NVTH), and elected member of the Royal Holland Society of Sciences and Humanities (KHMW). In addition, I am chair of the Scientific Advisory Board of the Netherlands Thrombosis Foundation and I act as reviewer for major journals in the Thrombosis & Hemostasis and chemistry fields and serve on grant reviewing boards of national and international granting agencies. I have published 160 papers with an average impact factor of 7.3 and h-index of 44.