Clinical Metabolomics by 1H-NMR Spectroscopy

The term metabolome covers the comprehensive determination of the small molecule content of various bio materials, e.g. blood, urine or tissue. Main advantages of 1H-NMR spectroscopy comprise its high reproducibility and minimal sample preparation. Furthermore, using only one internal standard enables quantification of metabolite concentrations. In summary, NMR-based metabolomics has a great potential to derive novel biomarkers as well as to improve our understanding of the underlying pathophysiology.